<<<<<<< HEAD ======= >>>>>>> 3d2926dbfc758e5506503989fb153426f89151ce Sensory Gating <<<<<<< HEAD ======= >>>>>>> 3d2926dbfc758e5506503989fb153426f89151ce <<<<<<< HEAD <<<<<<< HEAD ======= >>>>>>> 3d2926dbfc758e5506503989fb153426f89151ce
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What is sensory gating?

P50 - suppresses auditory stimuli after 50 ms
N100 - triggers attention to stimuli
P200 - allocates attention to auditory stimuli

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Note: “P” refers to a positive-going voltage peak; “N” refers to a negative-going peak. The number refers to the milliseconds following a stimulus when the given ERP component reaches its peak.

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Do adolescents and young adults with ASD have sensory gating deficits?

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Discussion of:

Chien, Y.-L., Hsieh, M. H., & Gau, S. S.-F. (2019). P50-N100-P200 sensory gating deficits in adolescents and young adults with autism spectrum disorders. Progress in Neuro-psychopharmacology & Biological Psychiatry, 95, 109683. Retrieved from http://dx.doi.org/10.1016/j.pnpbp.2019.109683

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<<<<<<< HEAD Participant results ======= Participant results >>>>>>> 3d2926dbfc758e5506503989fb153426f89151ce

Participant results


<<<<<<< HEAD Comparison of P50, N100, and P200 parameters ======= Comparison of P50, N100, and P200 parameters >>>>>>> 3d2926dbfc758e5506503989fb153426f89151ce

Comparison of P50, N100, and P200 parameters

There are no group correlates between P50 and P200 sensory gating.

N100 Gating Deficits in participants with ASD

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EEG Sensory Gating

EEG Sensory Gating


Figure 1: EEG Sensory Gating

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Independent of ASD diagnosis, N100 gating deficits were strongly correlated with sensory sensitivity. N100 sensory gates were the best indicator of an ASD diagnosis.

P200 gating was correlated with attention switching difficulty in ASD participants, even though there was no difference in the gating itself between the two groups.

Lack of P50 suppression had negative associations with social deficits in ASD, though the difference between the two groups was not significant enough to differentiate between the TDC and ASD groups.

Group Discussion Questions

1. Why do you think N100 gating had a strong correlation to sensory sensitivity?

2. What does the correlation between the P200 and attention switching difficulty imply?

3. Do you think the study is reproducible?

4. What other neurological disorders might have sensory gating deficits?

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